Latest Intelligence on Oncology

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Type Product title / description Pub Price
CommentWire
CommentWire

ZymoGenetics: early hope for late-stage disease

ZymoGenetics has reported positive results from its phase Ia study of IL-21 in patients with metastatic melanoma and metastatic renal cell carcinoma. This announcement warrants further studies of IL-21 in these indications, which is welcome news for ZymoGenetics and development partner Novo Nordisk. However, competition is already on the horizon, in the form of Bayer/Onyx' Nexavar.

Published By Datamonitor
15 Nov 2005
CommentWire
CommentWire

Zeltia: opening up options for ovarian cancer

Following promising Phase II trial results, Zeltia has announced the initiation of an international Phase III clinical trial to investigate a combination of Yondelis and Caelyx. Investigating Yondelis in relapsed ovarian cancer patients theoretically allows for its use in multiple lines of treatment, thereby greatly increasing its future commercial potential.

Published By Datamonitor
05 Apr 2005
CommentWire
CommentWire

Zeltia: files for approval of Yondelis for ovarian cancer in the US

Zeltia/Johnson & Johnson are seeking US approval for Yondelis, following a pivotal Phase III trial in second-line ovarian cancer therapy. However, approval in this indication may only marginally increase the commercial potential of Yondelis, as competition from established platinum-based chemotherapy agents will restrict the drug's market potential.

Published By Datamonitor
24 Nov 2008
Expert View
Expert View

Zelboraf's approval demonstrates a significant shift toward personalized cancer therapy

The FDA has approved Zelboraf and Roche's companion diagnostic test for BRAF V600E mutation-positive metastatic melanoma. The joint approval is the first example of co-development and demonstrates the movement toward personalized cancer therapy, and Zelboraf's impressive efficacy data and the availability of a test will ensure rapid uptake.

Published By Datamonitor
18 Aug 2011
CommentWire
CommentWire

Xenova/QLT: tackling multidrug resistance

UK biotech Xenova and its North American ally QLT will trial tariquidar for multidrug resistance in non-small cell lung cancer. As long as the results are positive, tariquidar should have a bright future: multidrug resistance is an increasingly serious problem in cancer treatment, and the developers look set to provide strong marketing support.

Published By Datamonitor
11 Jul 2002
CommentWire
CommentWire

Xanthus: more hurdles to clear for Symadex

Xanthus Life Sciences has begun dosing patients in a phase II trial of Symadex in recurrent colorectal cancer. While this is clearly a positive step in Symandex' development, the drug candidate still has phase III trials to contend with and, even if Symandex proves fit for launch here, Xanthus will need to find a marketing partner to help it achieve commercial success in the tough cancer market.

Published By Datamonitor
17 Jan 2006
CommentWire
CommentWire

Xanthus Pharmaceuticals: trial hopes to meet unmet need in secondary leukemia

Xanthus Pharmaceuticals has begun patient dosing in a Phase III trial of its drug Xanafide. Patients with secondary acute myeloid leukemia are poorly served by existing drug therapy; physicians are therefore likely to be enthusiastic about a drug which can improve treatment outcomes. At this stage of development, however, it is too early to forecast the chances of Xanthus's drug being successful.

Published By Datamonitor
10 Oct 2007
CommentWire
CommentWire

Wyeth: Torisel valuable for poor-risk patients

The European Commission has granted regulatory approval to Wyeth's Torisel, making it the first mTOR kinase inhibitor to reach the EU market. While renal cell carcinoma patients are becoming increasingly well served in terms of treatment options, Torisel represents a valuable addition for poor-risk patients, who traditionally have been the most difficult to treat.

Published By Datamonitor
27 Nov 2007
CommentWire
CommentWire

Wyeth: breast cancer prospects receive a blow

Wyeth has discontinued a phase III trial of temsirolimus plus letrozole in metastatic post-menopausal hormone-receptor positive breast cancer. This is a significant blow for the company due to the loss of earnings potential in the congested but lucrative breast cancer market. However, temsirolimus remains under development for a number of other tumors, and so hope for the drug candidate remains.

Published By Datamonitor
23 Mar 2006
CommentWire
CommentWire

Women's health: tamoxifen may do more harm than good

While the drug is undeniably highly effective at treating breast cancer, some of the efforts to use it as a preventative medicine may be more questionable. For many women, the side effects could prove more dangerous than the risk of breast cancer. More studies need to be carried out to determine exactly which groups will benefit from the drug.

Published By Datamonitor
05 Nov 2001

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